Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis

OBJECTIVE: Regulatory T (Treg) cell mediated suppression of effector T (Teff) cells is impaired in juvenile idiopathic arthritis (JIA); however, the basis for this dysfunction is incompletely understood. Animal models of autoimmunity and immunodeficiency demonstrate that a diverse Treg repertoire is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arthritis Rheumatol
Prif Awduron: Henderson, Lauren A., Volpi, Stefano, Frugoni, Francesco, Janssen, Erin, Kim, Susan, Sundel, Robert P., Dedeoglu, Fatma, Lo, Mindy S., Hazen, Melissa M., Son, Mary Beth, Mathieu, Ronald, Zurakowski, David, Yu, Neng, Lebedeva, Tatiana, Fuhlbrigge, Robert C., Walter, Jolan E., Lee, Yu Nee, Nigrovic, Peter A., Notarangelo, Luigi D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398095/
https://ncbi.nlm.nih.gov/pubmed/26815131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39606
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