The Length of N-Glycans of Recombinant H5N1 Hemagglutinin Influences the Oligomerization and Immunogenicity of Vaccine Antigen

Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of g...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Macioła, Agnieszka Katarzyna, Pietrzak, Maria Anna, Kosson, Piotr, Czarnocki-Cieciura, Mariusz, Śmietanka, Krzysztof, Minta, Zenon, Kopera, Edyta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397403/
https://ncbi.nlm.nih.gov/pubmed/28473830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00444
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