Binding site density enables paralog-specific activity of SLM2 and Sam68 proteins in Neurexin2 AS4 splicing control

SLM2 and Sam68 are splicing regulator paralogs that usually overlap in function, yet only SLM2 and not Sam68 controls the Neurexin2 AS4 exon important for brain function. Herein we find that SLM2 and Sam68 similarly bind to Neurexin2 pre-mRNA, both within the mouse cortex and in vitro. Protein domai...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Danilenko, Marina, Dalgliesh, Caroline, Pagliarini, Vittoria, Naro, Chiara, Ehrmann, Ingrid, Feracci, Mikael, Kheirollahi-Chadegani, Mahsa, Tyson-Capper, Alison, Clowry, Gavin J, Fort, Philippe, Dominguez, Cyril, Sette, Claudio, Elliott, David J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2017
Gaiak:
RNA
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397175/
https://ncbi.nlm.nih.gov/pubmed/27994030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1277
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