Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease

The pathogenesis of hepatic encephalopathy (HE) in cirrhosis is multifactorial and ammonia is thought to play a key role. Astroglial dysfunction is known to be present in HE. Astrocytes are extensively connected by gap junctions formed of connexins, which also exist as functional hemichannels allowi...

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Vydáno v:Hepatology
Hlavní autoři: Hadjihambi, Anna, De Chiara, Francesco, Hosford, Patrick S., Habtetion, Abeba, Karagiannis, Anastassios, Davies, Nathan, Gourine, Alexander V., Jalan, Rajiv
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Liver Failure/Cirrhosis/Portal Hypertension
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396295/
https://ncbi.nlm.nih.gov/pubmed/28066916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29031
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