Antiprotozoal Nitazoxanide Derivatives: Synthesis, Bioassays and QSAR Study Combined with Docking for Mechanistic Insight

In view of the serious health problems concerning infectious diseases in heavily populated areas, we followed the strategy of lead compound diversification to evaluate the near-by chemical space for new organic compounds. To this end, twenty derivatives of nitazoxanide (NTZ) were synthesized and tes...

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Vydáno v:Curr Comput Aided Drug Des
Hlavní autoři: Scior, Thomas, Lozano-Aponte, Jorge, Ajmani, Subhash, Hernández-Montero, Eduardo, Chávez-Silva, Fabiola, Hernández-Núñez, Emanuel, Moo-Puc, Rosa, Fraguela-Collar, Andres, Navarrete-Vázquez, Gabriel
Médium: Artigo
Jazyk:Inglês
Vydáno: Bentham Science Publishers 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396257/
https://ncbi.nlm.nih.gov/pubmed/25872791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1573409911666150414145937
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