VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation

BACKGROUND: VEPH1 is amplified in several cancers including ovarian but its impact on tumour progression is unknown. Previous work has shown that VEPH1 inhibits TGFβ signalling while its Drosophila ortholog increases tissue growth, raising the possibility that VEPH1 could impact tumour growth or pro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Cancer
Egile Nagusiak: Shathasivam, Premalatha, Kollara, Alexandra, Spybey, Thomasina, Park, Soyeon, Clarke, Blaise, Ringuette, Maurice J, Brown, Theodore J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Molecular Diagnostics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396109/
https://ncbi.nlm.nih.gov/pubmed/28301874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.51
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