VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation

BACKGROUND: VEPH1 is amplified in several cancers including ovarian but its impact on tumour progression is unknown. Previous work has shown that VEPH1 inhibits TGFβ signalling while its Drosophila ortholog increases tissue growth, raising the possibility that VEPH1 could impact tumour growth or pro...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Shathasivam, Premalatha, Kollara, Alexandra, Spybey, Thomasina, Park, Soyeon, Clarke, Blaise, Ringuette, Maurice J, Brown, Theodore J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396109/
https://ncbi.nlm.nih.gov/pubmed/28301874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.51
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