Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels

BACKGROUND: Grb2-associated binder 2 (Gab2) is a scaffolding protein that serves as a critical signaling amplifier downstream of tyrosine kinase receptors. Our previous study has shown that Gab2 induces epithelial-to-mesenchymal transition (EMT) and promotes metastasis in colorectal cancer (CRC). Ho...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Ding, Chenbo, Luo, Junmin, Fan, Xiaobo, Li, Longmei, Li, Shanshan, Wen, Kunming, Feng, Jihong, Wu, Guoqiu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395829/
https://ncbi.nlm.nih.gov/pubmed/28420432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0524-2
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