Rac1 GTPase silencing counteracts microgravity-induced effects on osteoblastic cells

Bone cells exposed to real microgravity display alterations of their cytoskeleton and focal adhesions, two major mechanosensitive structures. These structures are controlled by small GTPases of the Ras homology (Rho) family. We investigated the effects of RhoA, Rac1, and Cdc42 modulation of osteobla...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Guignandon, Alain, Faure, Céline, Neutelings, Thibaut, Rattner, Aline, Mineur, Pierre, Linossier, Marie-Thérèse, Laroche, Norbert, Lambert, Charles, Deroanne, Christophe, Nusgens, Betty, Demets, René, Colige, Alain, Vico, Laurence
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2014
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395736/
https://ncbi.nlm.nih.gov/pubmed/24903274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-249714
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