Rac1 GTPase silencing counteracts microgravity-induced effects on osteoblastic cells

Bone cells exposed to real microgravity display alterations of their cytoskeleton and focal adhesions, two major mechanosensitive structures. These structures are controlled by small GTPases of the Ras homology (Rho) family. We investigated the effects of RhoA, Rac1, and Cdc42 modulation of osteobla...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Guignandon, Alain, Faure, Céline, Neutelings, Thibaut, Rattner, Aline, Mineur, Pierre, Linossier, Marie-Thérèse, Laroche, Norbert, Lambert, Charles, Deroanne, Christophe, Nusgens, Betty, Demets, René, Colige, Alain, Vico, Laurence
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395736/
https://ncbi.nlm.nih.gov/pubmed/24903274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-249714
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