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Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2
BACE1 was discovered as the β-secretase for initiating the cleavage of amyloid precursor protein (APP) at the β-secretase site, while its close homology BACE2 cleaves APP within the β-amyloid (Aβ) domain region and shows distinct cleavage preferences in vivo. Inhibition of BACE1 proteolytic activity...
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| Published in: | Front Mol Neurosci |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Frontiers Media S.A.
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5395628/ https://ncbi.nlm.nih.gov/pubmed/28469554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00097 |
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