Increased Expression of Reticulon 3 in Neurons Leads to Reduced Axonal Transport of β Site Amyloid Precursor Protein-cleaving Enzyme 1

BACE1 is the sole enzyme responsible for cleaving amyloid precursor protein at the β-secretase site, and this cleavage initiates the generation of β-amyloid peptide (Aβ). Because amyloid precursor protein is predominantly expressed by neurons and deposition of Aβ aggregates in the human brain is hig...

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Detalhes bibliográficos
Main Authors: Deng, Minzi, He, Wanxia, Tan, Ya, Han, Hailong, Hu, Xiangyou, Xia, Kun, Zhang, Zhuohua, Yan, Riqiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798490/
https://ncbi.nlm.nih.gov/pubmed/24005676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480079
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