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Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction
The preparation of unsaturated secondary lactams via the palladium-catalyzed cyclization of O-phenyl hydroxamates onto a pendent alkene is reported. This method provides rapid access to a broad range of lactams that are widely useful building blocks in alkaloid synthesis. Mechanistic studies support...
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| Published in: | J Am Chem Soc |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5395365/ https://ncbi.nlm.nih.gov/pubmed/27754648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08932 |
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