Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation

Medulloblastomas comprise a heterogeneous group of tumours and can be subdivided into four molecular subgroups (WNT, SHH, Group 3 and Group 4) with distinct prognosis, biological behaviour and implications for targeted therapies. Few experimental models exist of the aggressive and poorly characteriz...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sandén, Emma, Dyberg, Cecilia, Krona, Cecilia, Gallo-Oller, Gabriel, Olsen, Thale Kristin, Enríquez Pérez, Julio, Wickström, Malin, Estekizadeh, Atosa, Kool, Marcel, Visse, Edward, Ekström, Tomas J., Siesjö, Peter, Inge Johnsen, John, Darabi, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394470/
https://ncbi.nlm.nih.gov/pubmed/28417956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46366
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