Cognate antigen engagement on parenchymal cells stimulates CD8(+) T cell proliferation in situ

T-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then migrate to inflamed tissues, but further T-cell stimulation in these parenchymal target sites is not well understood. Here we show that T-cell expansion within inflamed...

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Publicado no:Nat Commun
Main Authors: Sutherland, Robyn M., Londrigan, Sarah L., Brady, Jamie L., Carrington, Emma M., Marchingo, Julia M., Heinzel, Susanne, Hodgkin, Philip D., Graham, Kate L., Kay, Thomas W., Zhan, Yifan, Lew, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394288/
https://ncbi.nlm.nih.gov/pubmed/28401883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14809
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