Selected TLR ligands and viruses promote helper-independent CTL priming by upregulating CD40L (CD154) on dendritic cells

CD40L on CD4(+) T cells has been shown to license dendritic cells (DC) via CD40 to prime CTL responses. Surprisingly, we found that the converse (CD40L on DC) was also important. Anti-CD40L treatment decreases endogenous CTL responses to both OVA and influenza infection even in the absence of CD4(+)...

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Main Authors: Johnson, Susan, Zhan, Yifan, Mount, Adele M, Bedoui, Sammy, Brady, Jamie L, Carrington, Emma M, Belz, Gabrielle T, Sutherland, Robyn M, Heath, William R, Lew, Andrew M
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694753/
https://ncbi.nlm.nih.gov/pubmed/19200758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.11.015
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