Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency

CONTEXT: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that specifically cleaves IGFBP-3 and IGFBP-5. Mutations in the PAPP-A2 gene have recently been shown to cause postnatal growth failure in humans, with specific skeletal features, due to the resulting decrease in IGF-1...

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Gepubliceerd in:J Clin Endocrinol Metab
Hoofdauteurs: Muñoz-Calvo, María T., Barrios, Vicente, Pozo, Jesús, Chowen, Julie A., Martos-Moreno, Gabriel Á., Hawkins, Federico, Dauber, Andrew, Domené, Horacio M., Yakar, Shoshana, Rosenfeld, Ron G., Pérez-Jurado, Luis A., Oxvig, Claus, Frystyk, Jan, Argente, Jesús
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Endocrine Society 2016
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Special Features
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393598/
https://ncbi.nlm.nih.gov/pubmed/27648969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2016-2751
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