Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease

CONTEXT: Cushing disease, due to pituitary corticotroph tumor ACTH hypersecretion, drives excess adrenal cortisol production with adverse morbidity and mortality. Loss of glucocorticoid negative feedback on the hypothalamic-pituitary-adrenal axis leads to autonomous transcription of the corticotroph...

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Pubblicato in:J Clin Endocrinol Metab
Autori principali: Liu, Ning-Ai, Araki, Takako, Cuevas-Ramos, Daniel, Hong, Jiang, Ben-Shlomo, Anat, Tone, Yukiko, Tone, Masahide, Melmed, Shlomo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393529/
https://ncbi.nlm.nih.gov/pubmed/25942479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-1606
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