5-Hydroxymethylcytosine Promotes Proliferation of Human Uterine Leiomyoma: A Biological Link to a New Epigenetic Modification in Benign Tumors

CONTEXT: Uterine leiomyoma, or fibroids, represent the most common benign tumors of the female reproductive tract. A newly discovered epigenetic modification, 5-hydroxymethylation (5-hmC), and its regulators, the TET (Ten Eleven Translocation) enzymes, were implicated in the pathology of malignant t...

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Bibliographic Details
Published in:J Clin Endocrinol Metab
Main Authors: Navarro, Antonia, Yin, Ping, Ono, Masanori, Monsivais, Diana, Moravek, Molly B., Coon, John S., Dyson, Matthew T., Wei, Jian-Jun, Bulun, Serdar E.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2014
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JCEM Online: Advances in Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393501/
https://ncbi.nlm.nih.gov/pubmed/25057885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-2264
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