Oligosaccharyltransferase Inhibition Induces Senescence in RTK-Driven Tumor Cells

Asparagine (N)-linked glycosylation is a protein modification critical for glycoprotein folding, stability, and cellular localization. To identify small molecules that inhibit new targets in this biosynthetic pathway, we initiated a cell-based high throughput screen and lead compound optimization ca...

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Publicat a:Nat Chem Biol
Autors principals: Lopez-Sambrooks, Cecilia, Shrimal, Shiteshu, Khodier, Carol, Flaherty, Daniel P., Rinis, Natalie, Charest, Jonathan C., Gao, Ningguo, Zhao, Peng, Wells, Lance, Lewis, Timothy A., Lehrman, Mark A., Gilmore, Reid, Golden, Jennifer E., Contessa, Joseph N.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393272/
https://ncbi.nlm.nih.gov/pubmed/27694802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2194
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