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Editing N-Glycan Site Occupancy with Small Molecule Oligosaccharyltransferase (OST) Inhibitors
The oligosaccharyltransferase (OST) is a multisubunit enzyme complex that N-glycosylates proteins in the secretory pathway and is considered to be constitutive and unregulated. However, small molecule OST inhibitors such as NGI-1 provide a pharmacological approach for regulating N-linked glycosylati...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6337728/ https://ncbi.nlm.nih.gov/pubmed/30078634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.07.005 |
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