Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages

The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype pos...

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Detalles Bibliográficos
Publicado en:J Lipid Res
Autores principales: Vermeulen, Ilke, Baird, Mark, Al-Dulayymi, Juma, Smet, Muriel, Verschoor, Jan, Grooten, Johan
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392746/
https://ncbi.nlm.nih.gov/pubmed/28193630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M073171
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