Antigen-Presenting Human γδ T Cells Promote Intestinal CD4(+) T Cell Expression of IL-22 and Mucosal Release of Calprotectin

The cytokine IL-22 plays a critical role in mucosal barrier defense, but the mechanisms that promote IL-22 expression in the human intestine remain poorly understood. As human microbe–responsive Vγ9/Vδ2 T cells are abundant in the gut and recognize microbiota-associated metabolites, we assessed thei...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Tyler, Christopher J., McCarthy, Neil E., Lindsay, James O., Stagg, Andrew J., Moser, Bernhard, Eberl, Matthias
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: AAI 2017
Pynciau:
Clinical and Human Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392732/
https://ncbi.nlm.nih.gov/pubmed/28330898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700003
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