Phenformin enhances the efficacy of ERK inhibition in NF1-mutant melanoma

Inactivation of the tumor suppressor neurofibromin 1 (NF1) presents a newly characterized melanoma subtype, for which currently no targeted therapies are clinically available. Pre-clinical studies suggest that ERK inhibitors are likely to provide benefit, albeit with limited efficacy as single agent...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Trousil, Sebastian, Chen, Shuang, Mu, Chan, Shaw, Fiona M., Yao, Zhan, Ran, Yuping, Shakuntala, Tiwari, Merghoub, Taha, Manstein, Dieter, Rosen, Neal, Cantley, Lewis C., Zippin, Jonathan H., Zheng, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392423/
https://ncbi.nlm.nih.gov/pubmed/28143781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2017.01.013
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