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The structure of a nucleolytic ribozyme that employs a catalytic metal ion

The TS ribozyme (originally called twister-sister) is a nucleolytic catalytic RNA. We present a crystal structure of the ribozyme in a pre-reactive conformation. Two co-axial helical stacks are organized by a three-way junction and two tertiary contacts. Five divalent metal ions are directly coordin...

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Pubblicato in:Nat Chem Biol
Autori principali: Liu, Yijin, Wilson, Timothy J., Lilley, David M.J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392355/
https://ncbi.nlm.nih.gov/pubmed/28263963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2333
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