Using high-sensitivity sequencing for the detection of mutations in BTK and PLCγ2 genes in cellular and cell-free DNA and correlation with progression in patients treated with BTK inhibitors

Patients with chronic lymphocytic leukemia (CLL) that develop resistance to Bruton tyrosine kinase (BTK) inhibitors are typically positive for mutations in BTK or phospholipase c gamma 2 (PLCγ2). We developed a high sensitivity (HS) assay utilizing wild-type blocking polymerase chain reaction achiev...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Albitar, Adam, Ma, Wanlong, DeDios, Ivan, Estella, Jeffrey, Ahn, Inhye, Farooqui, Mohammed, Wiestner, Adrian, Albitar, Maher
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392298/
https://ncbi.nlm.nih.gov/pubmed/28212557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15316
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