Using high-sensitivity sequencing for the detection of mutations in BTK and PLCγ2 genes in cellular and cell-free DNA and correlation with progression in patients treated with BTK inhibitors

Patients with chronic lymphocytic leukemia (CLL) that develop resistance to Bruton tyrosine kinase (BTK) inhibitors are typically positive for mutations in BTK or phospholipase c gamma 2 (PLCγ2). We developed a high sensitivity (HS) assay utilizing wild-type blocking polymerase chain reaction achiev...

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Publicado en:Oncotarget
Autores principales: Albitar, Adam, Ma, Wanlong, DeDios, Ivan, Estella, Jeffrey, Ahn, Inhye, Farooqui, Mohammed, Wiestner, Adrian, Albitar, Maher
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392298/
https://ncbi.nlm.nih.gov/pubmed/28212557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15316
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