Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer

Persistent STAT3 activation is seen in many tumor cells and promotes malignant transformation. Here, we investigated whether capsazepine (Capz), a synthetic analogue of capsaicin, exerts anticancer effects by inhibiting STAT3 activation in prostate cancer cells. Capz inhibited both constitutive and...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Lee, Jong Hyun, Kim, Chulwon, Baek, Seung Ho, Ko, Jeong-Hyeon, Lee, Seok Geun, Yang, Woong Mo, Um, Jae-Young, Sethi, Gautam, Ahn, Kwang Seok
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392279/
https://ncbi.nlm.nih.gov/pubmed/27458171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10775
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