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Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model

The Hsp90 family of molecular chaperones includes the cytosolic isoforms Hsp90a and Hsp90β and the mitochondrial isoform Trap1. Hsp90a/βsupport a large number of client proteins in the cytoplasm and the nucleus whereas Trap1 regulates oxidative phosphorylation in mitochondria. Many of the associated...

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Publicat a:Oncotarget
Autors principals: Vartholomaiou, Evangelia, Madon-Simon, Marta, Hagmann, Stéphane, Mühlebach, Guillaume, Wurst, Wolfgang, Floss, Thomas, Picard, Didier
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392260/
https://ncbi.nlm.nih.gov/pubmed/28407697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15659
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