FCGR Polymorphisms Influence Response to IL-2 in Metastatic Renal Cell Carcinoma

BACKGROUND: Fc-gamma receptors (FCGRs) are expressed on immune cells, bind to antibodies, and trigger antibody-induced cell-mediated anti-tumor responses when tumor-reactive antibodies are present. The affinity of the FCGR/antibody interaction is variable and dependent upon FCGR polymorphisms. Prior...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Erbe, Amy K, Wang, Wei, Goldberg, Jacob, Gallenberger, Mikayla, Kim, KyungMann, Carmichael, Lakeesha, Hess, Dustin, Mendonca, Eneida A, Song, Yiqiang, Hank, Jacquelyn A, Cheng, Su-Chun, Signoretti, Sabina, Atkins, Michael, Carlson, Alexander, Mier, James, Panka, David, McDermott, David F, Sondel, Paul M
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392177/
https://ncbi.nlm.nih.gov/pubmed/27742794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1874
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