Impact of the CYP2C19 Genotype on Voriconazole Exposure in Adults with Invasive Fungal Infections

OBJECTIVE: Voriconazole, a first line agent for the treatment of invasive fungal infections (IFIs), is metabolized by CYP2C19. A significant portion of patients fail to achieve therapeutic trough concentrations with standard weight-based voriconazole dosing, placing them at increased risk for treatm...

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Detaylı Bibliyografya
Yayımlandı:Pharmacogenet Genomics
Asıl Yazarlar: Hamadeh, Issam S., Klinker, Kenneth P., Borgert, Samuel J., Richards, Ashley I., Li, Wenhui, Mangal, Naveen, Hiemenz, John W., Schmidt, Stephan, Langaee, Taimour Y., Peloquin, Charles A., Johnson, Julie A., Cavallari, Larisa H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391994/
https://ncbi.nlm.nih.gov/pubmed/28306618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000277
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