Impact of the CYP2C19 Genotype on Voriconazole Exposure in Adults with Invasive Fungal Infections

OBJECTIVE: Voriconazole, a first line agent for the treatment of invasive fungal infections (IFIs), is metabolized by CYP2C19. A significant portion of patients fail to achieve therapeutic trough concentrations with standard weight-based voriconazole dosing, placing them at increased risk for treatm...

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Detalhes bibliográficos
Publicado no:Pharmacogenet Genomics
Main Authors: Hamadeh, Issam S., Klinker, Kenneth P., Borgert, Samuel J., Richards, Ashley I., Li, Wenhui, Mangal, Naveen, Hiemenz, John W., Schmidt, Stephan, Langaee, Taimour Y., Peloquin, Charles A., Johnson, Julie A., Cavallari, Larisa H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391994/
https://ncbi.nlm.nih.gov/pubmed/28306618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000277
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