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Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation
Gain-of-function (GOF) mutations in the STAT1 gene are critical for the onset of chronic mucocutaneous candidiasis (CMC) disease. However, the molecular basis for the gain of STAT1 function remains largely unclear. Here, we investigated the structural features of STAT1 GOF residues to better underst...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5391754/ https://ncbi.nlm.nih.gov/pubmed/28258222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753848 |
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