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R-Ras Controls Membrane Protrusion and Cell Migration through the Spatial Regulation of Rac and Rho

Although it is known that the spatial coordination of Rac and Rho activity is essential for cell migration, the molecular mechanisms regulating these GTPases during migration are unknown. We found that the expression of constitutively activated R-Ras (38V) blocked membrane protrusion and random migr...

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Autors principals: Wozniak, Michele A., Kwong, Lina, Chodniewicz, David, Klemke, Richard L., Keely, Patricia J.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC539154/
https://ncbi.nlm.nih.gov/pubmed/15525681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-04-0277
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