Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly

The lentiviral accessory proteins Vpx and Vpr are known to utilize CRL4 (DCAF1) E3 ligase to induce the degradation of the host restriction factor SAMHD1 or host helicase transcription factor (HLTF), respectively. Selective disruption of viral CRL4 (DCAF1) E3 ligase could be a promising antiviral st...

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Bibliographic Details
Published in:J Virol
Main Authors: Wang, Hong, Guo, Haoran, Su, Jiaming, Rui, Yajuan, Zheng, Wenwen, Gao, Wenying, Zhang, Wenyan, Li, Zhaolong, Liu, Guanchen, Markham, Richard B., Wei, Wei, Yu, Xiao-Fang
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391453/
https://ncbi.nlm.nih.gov/pubmed/28202763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00225-17
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