Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly

The lentiviral accessory proteins Vpx and Vpr are known to utilize CRL4 (DCAF1) E3 ligase to induce the degradation of the host restriction factor SAMHD1 or host helicase transcription factor (HLTF), respectively. Selective disruption of viral CRL4 (DCAF1) E3 ligase could be a promising antiviral st...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Wang, Hong, Guo, Haoran, Su, Jiaming, Rui, Yajuan, Zheng, Wenwen, Gao, Wenying, Zhang, Wenyan, Li, Zhaolong, Liu, Guanchen, Markham, Richard B., Wei, Wei, Yu, Xiao-Fang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391453/
https://ncbi.nlm.nih.gov/pubmed/28202763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00225-17
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