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Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines
Cisplatin is a highly-effective and widely-used chemotherapeutic agent that causes ototoxicity in many patients. Pharmacogenomic studies of key genes controlling drug biotransformation identified variants in thiopurine methyltransferase (TPMT) as predictors of cisplatin-induced ototoxicity, although...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5391095/ https://ncbi.nlm.nih.gov/pubmed/28406961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175711 |
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