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Peptide probes derived from pertuzumab by molecular dynamics modeling for HER2 positive tumor imaging
A high level of HER2 expression in breast cancer correlates with a higher tumor growth rate, high metastatic potential, and a poor long-term patient survival rate. Pertuzumab, a human monoclonal antibody, can reduce the effect of HER2 overexpression by preventing HER2 dimerization. In this study, a...
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| Publicat a: | PLoS Comput Biol |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5390981/ https://ncbi.nlm.nih.gov/pubmed/28406988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005441 |
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