Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

Although mutations in several genes with diverse functions have been known to cause amyotrophic lateral sclerosis (ALS), it is unknown to what extent causal mutations impinge on common pathways that drive motor neuron (MN)-specific neurodegeneration. In this study, we combined induced pluripotent st...

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Détails bibliographiques
Publié dans:Stem Cell Reports
Auteurs principaux: Bhinge, Akshay, Namboori, Seema C., Zhang, Xiaoyu, VanDongen, Antonius M.J., Stanton, Lawrence W.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390134/
https://ncbi.nlm.nih.gov/pubmed/28366453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.02.019
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