Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

Summary: Although mutations in several genes with diverse functions have been known to cause amyotrophic lateral sclerosis (ALS), it is unknown to what extent causal mutations impinge on common pathways that drive motor neuron (MN)-specific neurodegeneration. In this study, we combined induced pluri...

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Hlavní autoři:	Akshay Bhinge, Seema C. Namboori, Xiaoyu Zhang, Antonius M.J. VanDongen, Lawrence W. Stanton
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2017-04-01
Edice:	Stem Cell Reports
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2213671117300863
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