Lineage Specification from Prostate Progenitor Cells Requires Gata3-Dependent Mitotic Spindle Orientation

During prostate development, basal and luminal cell lineages are generated through symmetric and asymmetric divisions of bipotent basal cells. However, the extent to which spindle orientation controls division symmetry or cell fate, and the upstream factors regulating this process, are still elusive...

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Опубликовано в: :Stem Cell Reports
Главные авторы: Shafer, Maxwell E.R., Nguyen, Alana H.T., Tremblay, Mathieu, Viala, Sophie, Béland, Mélanie, Bertos, Nicholas R., Park, Morag, Bouchard, Maxime
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390093/
https://ncbi.nlm.nih.gov/pubmed/28285879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.02.004
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