Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes

VEGFA is an angiogenic factor secreted by tumors, in particular those with VEGFA amplification, as well as by macrophages and lymphocytes in the tumor microenvironment. Here we sought to define the presence of M1/M2 macrophages, PD-1-positive lymphocytes and PD-L1 tumoral and stromal expression in c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Burmeister, Katharina, Quagliata, Luca, Andreozzi, Mariacarla, Eppenberger-Castori, Serenella, Matter, Matthias S., Perrina, Valeria, Grobholz, Rainer, Jochum, Wolfram, Horber, Daniel, Moosmann, Peter, Lehmann, Frank, Köberle, Dieter, Ng, Charlotte K. Y., Piscuoglio, Salvatore, Tornillo, Luigi, Terracciano, Luigi M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389821/
https://ncbi.nlm.nih.gov/pubmed/28403223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175563
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