CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice

Duchenne muscular dystrophy (DMD), caused by mutations in the X-linked dystrophin gene (DMD), is characterized by fatal degeneration of striated muscles. Dilated cardiomyopathy is one of the most common lethal features of the disease. We deployed Cpf1, a unique class 2 CRISPR (clustered regularly in...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Zhang, Yu, Long, Chengzu, Li, Hui, McAnally, John R., Baskin, Kedryn K., Shelton, John M., Bassel-Duby, Rhonda, Olson, Eric N.
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2017
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389745/
https://ncbi.nlm.nih.gov/pubmed/28439558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1602814
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki