Development of a Δ(9)-Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability

PURPOSE: The aim of the present study was to evaluate the utility of the relatively hydrophilic Δ(9)-tetrahydrocannabinol (THC) prodrugs, mono and di-valine esters (THC-Val and THC-Val-Val) and the amino acid (valine)-dicarboxylic acid (hemisuccinate) ester (THC-Val-HS), with respect to ocular penet...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Adelli, Goutham R., Bhagav, Prakash, Taskar, Pranjal, Hingorani, Tushar, Pettaway, Sara, Gul, Waseem, ElSohly, Mahmoud A., Repka, Michael A., Majumdar, Soumyajit
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2017
Témata:
Glaucoma
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389743/
https://ncbi.nlm.nih.gov/pubmed/28399267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20757
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