Both Innate Immunity and Type 1 Humoral Immunity to Streptococcus pneumoniae Are Mediated by MyD88 but Differ in Their Relative Levels of Dependence on Toll-Like Receptor 2

Little is known regarding the role of Toll-like receptors (TLRs) in regulating protein- and polysaccharide-specific immunoglobulin (Ig) isotype production in response to an in vivo challenge with an extracellular bacterium. In this report we demonstrate that MyD88(−/−), but not TLR2(−/−), mice are m...

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Bibliographic Details
Main Authors: Khan, Abdul Q., Chen, Quanyi, Wu, Zheng-Qi, Paton, James C., Snapper, Clifford M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC538967/
https://ncbi.nlm.nih.gov/pubmed/15618166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.1.298-307.2005
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