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Fungal Metabolite Gliotoxin Targets Flavocytochrome b(558) in the Activation of the Human Neutrophil NADPH Oxidase
Fungal gliotoxin (GT) is a potent inhibitor of the O(2)(−)-generating NADPH oxidase of neutrophils. We reported that GT-treated neutrophils fail to phosphorylate p47(phox), a step essential for the enzyme activation, because GT prevents the colocalization of protein kinase C βII with p47(phox) on th...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC538966/ https://ncbi.nlm.nih.gov/pubmed/15618159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.1.235-244.2005 |
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