Fungal Metabolite Gliotoxin Targets Flavocytochrome b(558) in the Activation of the Human Neutrophil NADPH Oxidase

Fungal gliotoxin (GT) is a potent inhibitor of the O(2)(−)-generating NADPH oxidase of neutrophils. We reported that GT-treated neutrophils fail to phosphorylate p47(phox), a step essential for the enzyme activation, because GT prevents the colocalization of protein kinase C βII with p47(phox) on th...

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Autores principales: Nishida, Satoshi, Yoshida, Lucia S., Shimoyama, Takashi, Nunoi, Hiroyuki, Kobayashi, Toshihiro, Tsunawaki, Shohko
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Fungal and Parasitic Infections
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC538966/
https://ncbi.nlm.nih.gov/pubmed/15618159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.1.235-244.2005
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