PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c

The FADS1 and FADS2 genes in the FADS cluster encode the rate-limiting enzymes in the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs). Genetic variation in this region has been associated with a large number of diseases and traits many of them correlated to differences in metabolism o...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Pan, Gang, Ameur, Adam, Enroth, Stefan, Bysani, Madhusudhan, Nord, Helena, Cavalli, Marco, Essand, Magnus, Gyllensten, Ulf, Wadelius, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389558/
https://ncbi.nlm.nih.gov/pubmed/27932482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1186
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