Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole

Multiple G-quadruplex units in the 3΄-terminal overhang of human telomeric DNA can associate and form multimeric structures. The specific targeting of such distinctive higher-order G-quadruplexes might be a promising strategy for developing selective anticancer agents with fewer side effects. Howeve...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Hu, Ming-Hao, Chen, Shuo-Bin, Wang, Bo, Ou, Tian-Miao, Gu, Lian-Quan, Tan, Jia-Heng, Huang, Zhi-Shu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Chemical Biology and Nucleic Acid Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389520/
https://ncbi.nlm.nih.gov/pubmed/27923993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1195
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