Cytomegalovirus Restructures Lipid Rafts via US28/CDC42 Mediated Pathway Enhancing Cholesterol Efflux from Host Cells

Cytomegalovirus (HCMV) contains cholesterol, but how HCMV interacts with host cholesterol metabolism is unknown. We found that in human fibroblasts HCMV infection increased efflux of cellular cholesterol despite reducing the abundance of ABCA1. Mechanistically, viral protein US28 was acting through...

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Publicado no:Cell Rep
Main Authors: Low, Hann, Mukhamedova, Nigora, Cui, Huanhuan L., McSharry, Brian P., Avdic, Selmir, Hoang, Anh, Ditiatkovski, Michael, Liu, Yingying, Fu, Ying, Meikle, Peter J., Blomberg, Martin, Polyzos, Konstantinos A., Miller, William E., Religa, Piotr, Bukrinsky, Michael, Soderberg-Naucler, Cecilia, Slobedman, Barry, Sviridov, Dmitri
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389417/
https://ncbi.nlm.nih.gov/pubmed/27320924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.070
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