Cytomegalovirus Restructures Lipid Rafts via US28/CDC42 Mediated Pathway Enhancing Cholesterol Efflux from Host Cells

Cytomegalovirus (HCMV) contains cholesterol, but how HCMV interacts with host cholesterol metabolism is unknown. We found that in human fibroblasts HCMV infection increased efflux of cellular cholesterol despite reducing the abundance of ABCA1. Mechanistically, viral protein US28 was acting through...

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Pubblicato in:Cell Rep
Autori principali: Low, Hann, Mukhamedova, Nigora, Cui, Huanhuan L., McSharry, Brian P., Avdic, Selmir, Hoang, Anh, Ditiatkovski, Michael, Liu, Yingying, Fu, Ying, Meikle, Peter J., Blomberg, Martin, Polyzos, Konstantinos A., Miller, William E., Religa, Piotr, Bukrinsky, Michael, Soderberg-Naucler, Cecilia, Slobedman, Barry, Sviridov, Dmitri
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389417/
https://ncbi.nlm.nih.gov/pubmed/27320924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.070
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