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Atomic Resolution Structure of Monomorphic Aβ(42) Amyloid Fibrils

Amyloid-β (Aβ) is a 39–42 residue protein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggregates to form cross-β amyloid fibrils that are a hallmark of Alzheimer’s disease (AD). The most prominent forms of Aβ are Aβ(1–40) and Aβ(1–42), which differ by two amin...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Colvin, Michael T., Silvers, Robert, Ni, Qing Zhe, Can, Thach V., Sergeyev, Ivan, Rosay, Melanie, Donovan, Kevin J., Michael, Brian, Wall, Joseph, Linse, Sara, Griffin, Robert G.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389415/
https://ncbi.nlm.nih.gov/pubmed/27355699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b05129
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